Home - Products - Others - Other Targets - 7,12-DIMETHYLBENZ[A]ANTHRACENE

7,12-DIMETHYLBENZ[A]ANTHRACENE

CAS No. 57-97-6

7,12-DIMETHYLBENZ[A]ANTHRACENE ( DMBZA; DMBA )

Catalog No. M23108 CAS No. 57-97-6

7,12-Dimethylbenz[a]anthracene is a highly potent carcinogen that is activated by microsomal enzymes to a diol epoxide metabolite that binds covalently to DNA in mammalian cells, leading ultimately to tumor induction.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
100MG 55 In Stock
200MG Get Quote In Stock
500MG Get Quote In Stock
1G Get Quote In Stock

Biological Information

  • Product Name
    7,12-DIMETHYLBENZ[A]ANTHRACENE
  • Note
    Research use only, not for human use.
  • Brief Description
    7,12-Dimethylbenz[a]anthracene is a highly potent carcinogen that is activated by microsomal enzymes to a diol epoxide metabolite that binds covalently to DNA in mammalian cells, leading ultimately to tumor induction.
  • Description
    7,12-Dimethylbenz[a]anthracene (DMBA) is a polycyclic aromatic hydrocarbon (PAH) that has been found in tobacco smoke and diesel exhaust and has carcinogenic activity.It undergoes metabolic activation by numerous enzymes, including the cytochrome P450 (CYP450) isoform CYP1B1, as well as microsomal epoxide hydrolase (mEH), producing a variety of reactive metabolites that form DNA adducts in vivo, and it has been commonly used to induce tumor formation in various rodent models.DMBA increases proliferation and migration of, and induces epithelial-to-mesenchymal transition (EMT) in, MCF-10A breast cancer cells when used at a concentration of 5 μM.It also has immunosuppressant activity, inhibiting proliferation of isolated mouse splenic B- and T cells stimulated ex vivo with LPS or concanavalin A, respectively, when administered at doses of 50 and 100 mg/kg.Intragastric administration of DMBA (20 mg/animal) induces formation of mammary gland tumors in rats.
  • Synonyms
    DMBZA; DMBA
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    ——
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    57-97-6
  • Formula Weight
    256.3
  • Molecular Formula
    C20H16
  • Purity
    >98% (HPLC)
  • Solubility
    Soluble in toluene (50 mg/ml), acetone, chloroform, dichloromethane, ethanol, diethyl ether, n-octanol, and hot water (very slightly). Insoluble in cold water.
  • SMILES
    CC1=C2C=CC3=CC=CC=C3C2=C(C4=CC=CC=C14)C
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Rengarajan, T., Rajendran, P., Nandakumar, N., et al. Exposure to polycyclic aromatic hydrocarbons with special focus on cancer. Asian Pac. J. Trop. Biomed. 5(3), 182-189 (2015). 2. Csiszar, A., Balasubramanian, B., Tarantini, S., et al. Chemically induced carcinogenesis in rodent models of aging: Assessing organismal resilience to genotoxic stressors in geroscience research. Geroscience 41(2), 209-227 (2019). 3. Huberman, E., Chou, M.W., and Yang, S.K. Identification of 7,12-dimethylbenz[a]anthracene metabolites that lead to mutagenesis in mammalian cells. Proc. Natl. Acad. Sci. U.S.A. 76(2), 862-866 (1979).
molnova catalog
related products
  • (L)-Sodium lactate

    Sodium L-lactate is produced from pyruvate by the enzyme Lactate Dehydrogenase. Lactate production occurs during anaerobic glycolysis or in proliferatively active cells. L-Lactic Acid occurs in small quantities in the blood and muscle fluid of man and animals.

  • Oroxylin A

    Oroxylin A possesses abilities of inhibiting the ATRA-induced IL-6 production via modulation of LAP/LIP/CHOP in leukemia cell lines, which could providing a therapeutic strategy for RAS.

  • CH 5450

    CH 5450 (Z-Ile-Glu-Pro-Phe-Ome) is a short peptide inhibitor of chymase in the human heart.